NFL Week 5: Key injuries and betting odds report

As the NFL approaches Week 5 of the 2026 season, several key injuries and team performances are shaping betting lines and matchups. The Tampa Bay Buccaneers fall to a 0-4 record following Jalon Daniels’ first career start, as Baker Mayfield is expected to be sidelined for several weeks.

In other matchups, the Dallas Cowboys hold a significant advantage over the Buccaneers. Meanwhile, the Philadelphia Eagles face the Jacksonville Jaguars in London. The Eagles enter the game following a loss to the Rams, a contest in which they lost Saquon Barkley to injury and saw Jalen Hurts complete only 93 passing yards.