Ole Miss and Louisville face off in Top 25 Week 1 matchup

college football Ole Miss Rebels Louisville Cardinals NCAA Top 25 matchup

No. 9 Ole Miss and No. 24 Louisville are set to face each other in the only Top 25 matchup of Week 1. The game will take place at Nissan Stadium in Nashville on Sunday night, Sept. 6.

Ole Miss enters the season under new head coach Pete Golding, who took over following Lane Kiffin’s move to LSU. The Rebels are led by quarterback Trinidad Chambliss, a top Heisman candidate, following a 13-2 season that included a appearance in the College Football Playoff semifinals.

Louisville enters the matchup as a notable underdog, with some analysts suggesting they could cover a spread of 6.5 points. The Cardinals are looking to build on recent performances and maintain competitiveness against a high-ranking SEC opponent on a neutral field.