Periodontitis linked to 56% higher pancreatic cancer risk

A review published in the Journal of Clinical Medicine, analyzing eight studies involving 476,000 people, has found that individuals with periodontitis—chronic inflammation of the gums and supporting tooth tissues—face an approximately 56% higher risk of developing pancreatic cancer.

This finding builds upon previous research, including a 2024 review on digestive system cancers that noted a 35% increased risk. Scientists are investigating whether the spread of bacteria associated with periodontal disease or the effects of low-intensity chronic inflammation contribute to the link. Specifically, higher levels of antibodies against the bacterium Porphyromonas gingivalis have been associated with the disease.

Researchers note that because pancreatic cancer is relatively uncommon in the general population, a 56% relative increase may represent a small difference in absolute numbers. Further studies are required before implementing changes to prevention or screening strategies.