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Shingrix vaccine linked to lower dementia and cardiovascular risks
Recent large-scale studies suggest that the recombinant shingles vaccine, Shingrix, provides significant health benefits beyond preventing the herpes zoster virus. Research published in Nature Medicine by the University of Oxford indicates that recipients of Shingrix experienced a 9% reduction in cardiovascular disease burden over seven years compared to those who received the older, live-attenuated Zostavax vaccine. Specific findings include a 10% reduction in coronary heart disease, a 12% reduction in heart failure, and a 12% reduction in stroke risk among men.
Additionally, a study from Brown University involving over 500,000 individuals found that Shingrix is associated with a 24% lower risk of dementia in older adults. Another U.S. study highlighted the vaccine's effectiveness for patients with multiple sclerosis, noting it reduced shingles risk by up to 81% depending on insurance type.
Researchers utilized a natural experiment approach in the U.S., comparing groups vaccinated just before and after the 2017 transition from Zostavax to Shingrix to minimize healthy vaccine bias. While these observational studies show strong associations, experts note that clinical trials are required to confirm direct causality.
Entities
Brown University · GlaxoSmithKline · Maxime Taquet · NHS · Nature Medicine · Shingrix · TriNetX · University of Oxford · Zostavax
Claims
What the coverage asserts, and how many sources carry each claim.
- [● 5 SOURCES] Shingrix recipients showed a 10% reduction in coronary heart disease and a 12% reduction in heart failure compared to Zostavax recipients. www.insideprecisionmedicine.com · oxfordhealthbrc.nihr.ac.uk · www.ad-hoc-news.de · www.independent.co.uk · www.medicaldaily.com
- [DISPUTED] The recombinant Shingrix vaccine is associated with a 9% reduction in cardiovascular disease burden over seven years compared to the Zostavax vaccine. www.ilfogliettone.it · www.insideprecisionmedicine.com · www.it-boltwise.de · oxfordhealthbrc.nihr.ac.uk · www.ad-hoc-news.de · +3 more
- [● 4 SOURCES] A Brown University study found that the Shingrix vaccine is associated with a 24% reduction in dementia risk among older adults. radiokollasuyo.bo · www.insideprecisionmedicine.com · www.gbnews.com · www.pravda.sk
- [DISPUTED] Men receiving the Shingrix vaccine showed a 12% lower risk of stroke compared to those receiving Zostavax. www.insideprecisionmedicine.com · oxfordhealthbrc.nihr.ac.uk · www.ad-hoc-news.de · www.independent.co.uk · www.medicaldaily.com
- [○ 1 SOURCE] In a U.S. study, the recombinant zoster vaccine reduced shingles risk by 64% in patients with multiple sclerosis on Medicare and by 81% in those with private insurance. multiplesclerosisnewstoday.com