Women with PMOS face fourfold higher risk of heart disease, study shows

A systematic review and network meta‑analysis of 25 randomized controlled trials involving 1,453 women with polyendocrine metabolic ovarian syndrome (PMOS, formerly PCOS) identified several effective interventions for anxiety and depression. The most beneficial approaches included emotion‑focused therapy, peer‑support programs, and supplementation with omega‑3 fatty acids plus vitamin E.

Separately, a large U.S. claims‑based cohort study examined more than 413,000 women diagnosed with PMOS and compared them to over two million women without the condition. The analysis found that women with PMOS have a four‑times higher risk of developing cardiovascular disease, even after adjusting for hypertension, diabetes, obesity and other risk factors. Researchers stress that early diagnosis and lifestyle measures—such as maintaining a healthy weight, regular exercise, balanced diet, and smoking cessation—can mitigate this elevated risk.

Both pieces of research highlight the broader health implications of PMOS beyond reproductive symptoms, underscoring the need for comprehensive management of mental health and cardiovascular risk in affected women.