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2 clusters · 2 sources · 20 days · First seen · Last updated

Acute myeloid leukaemia research and treatment advances

Overview

Research into acute myeloid leukaemia (AML) has focused on identifying new therapeutic targets and improving clinical decision-making. Initial studies demonstrated that combining FLT3 kinase inhibition with Hedgehog pathway inhibition produced a synergistic anti-cancer effect, which selectively reduced the transport of specific proteins into extracellular vesicles.

Subsequent developments have expanded on drug combination strategies and diagnostic modeling. Researchers identified that a three-drug combination of inobrodib, venetoclax, and gilteritinib was more effective at targeting resilient leukemia stem cells in laboratory models than individual or dual treatments. Additionally, the development of the HSCT-64 machine-learning model utilizes transcriptomic data to assist clinicians in determining the necessity of hematopoietic stem cell transplantation for pediatric AML patients.

Entities

Chongqing Medical University · Foshan University · Sun Yat-sen University · Thomas Jefferson University · Acute myeloid leukemia

Timeline

  1. 1 day ago

    [HEALTH] 2 sources
    Advances in AML treatment target leukemia stem cells and transplant decisions

    New medical advancements in AML treatment include a three-drug combination to target leukemia stem cells and a machine-learning model to personalize stem cell transplant decisions for pediatric patients.

  2. 20 days ago

    [HEALTH] 2 sources
    Extracellular Vesicle Advances in AML Therapy and Human Milk Research

    Recent research shows combined FLT3 and Hedgehog inhibition alters AML extracellular vesicles, while a review outlines therapeutic prospects and challenges of human‑milk‑derived vesicles.

Sources

knowridge.com · newswise.com