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2 clusters · 4 sources · 2 days · First seen · Last updated

Biological research into aging and cellular senescence

Overview

Scientific research has identified specific biological mechanisms and proteins that contribute to the aging process and cellular decline.

Initial findings highlighted the role of the brain protein Menin in regulating aging via the hypothalamus. Studies indicated that declining Menin levels in mice are linked to increased brain inflammation, cognitive decline, reduced bone mass, and thinner skin. Researchers observed that restoring Menin or supplementing the amino acid D-serine could improve memory and physical markers in mice.

Subsequent reports focused on the protein PD-L2, which allows senescent, or “zombie,” cells to evade the immune system. These cells stop dividing but remain in the body, releasing inflammatory substances. Research published in the journal Cell Metabolism suggests that blocking PD-L2 can reduce the accumulation of these cells. Scientists believe PD-L2 could serve as both a therapeutic target to clear harmful cells and a blood-based biomarker to monitor cellular senescence.

Entities

PD-L2 · Cedars-Sinai Health Sciences University · Cell Metabolism · Menin · Xiamen University

Timeline

  1. [HEALTH] 2 sources
    PD-L2 protein identified as mechanism for senescent cell immune evasion

    Researchers have discovered that the PD-L2 protein helps harmful senescent cells evade the immune system, offering a potential new target for therapies to combat age-related health issues.

  2. [HEALTH] 2 sources
    Researchers identify key proteins linked to aging and cellular decline

    New research identifies the Menin protein and the PD-L2 protein as key factors in aging, potentially offering pathways to combat cognitive decline, inflammation, and the accumulation of senescent cells.

Sources

novini247.com · rocketnews.com · ruse24.bg · sciencedaily.com