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[SITUATION] · [ACTIVE] · [HEALTH]

2 clusters · 2 sources · 23 days · First seen · Last updated

Blood cancer research and treatment advancements

Overview

Medical research into aggressive blood cancers has focused on identifying new treatment pathways and molecular targets. Initial studies highlighted the effectiveness of allogeneic haematopoietic stem cell transplantation for hepatosplenic T-cell lymphoma, noting a 55% survival rate after three years in a multi-regional study. Additionally, researchers identified the TUT4/7 enzymes as potential drug targets for acute myeloid leukaemia (AML), suggesting that inhibiting these enzymes could improve efficacy when combined with drugs like venetoclax.

Subsequent developments have expanded these approaches. Clinical trials demonstrated success in treating aggressive multiple myeloma through personalized therapy adjusted to a tumor’s specific molecular biology. Further research into AML has introduced a method to combat the disease by using the molecule AcTor to disrupt the TSC2 protein. This technique prevents cancer cells from entering a defensive, energy-saving state, forcing them to exhaust their energy when combined with the drug ixazomib.

Entities

Case Western Reserve University · Institute of Cancer Research · University of Gothenburg · Royal Marsden NHS Foundation Trust · The Institute of Cancer Research

Timeline

  1. 2 days ago

    [HEALTH] 2 sources
    Medical researchers develop new approaches for aggressive blood cancers

    New medical advancements show promise in treating aggressive blood cancers through personalized molecular therapies and a novel method that exhausts leukemia cells' energy reserves.

  2. 25 days ago

    [HEALTH] 6 sources
    Medical researchers identify new treatment pathways for aggressive blood cancers

    New research highlights breakthroughs in treating aggressive blood cancers, including donor stem cell transplants for hepatosplenic T-cell lymphoma and new enzyme-targeting therapies for acute myeloid leukaemia

Sources

geekweek.interia.pl · naukawpolsce.pap.pl