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2 clusters · 13 sources · 21 days · First seen · Last updated

iPS cell heart muscle sheet clinical surgery in Japan

Overview

In September 2026, surgeons at Osaka Keisatsu Hospital in Japan performed the world’s first clinical surgery using commercially available heart muscle stem cell sheets to treat severe heart failure. The procedure involved transplanting three sheets of cardiomyocytes derived from induced pluripotent stem (iPS) cells into a woman in her 50s.

The therapy, known commercially as ‘RiHeart’ or ‘Reheart,’ was developed by the startup Cuorips Inc. (also referred to as QualiCEPT) based on technology from Professor Yoshiki Sawa and Nobel laureate Shinya Yamanaka. The treatment received conditional government approval in March.

The patient reported significant improvement in her ability to breathe and is preparing for discharge. To secure full authorization, the developer must use the treatment on 75 patients within seven years. The medical team and developer aim to expand the procedure to additional patients and facilities to further evaluate efficacy and safety.

Entities

Yoshiki Sawa · Osaka Keisatsu Hospital · Shinya Yamanaka · Osaka · Japan

Timeline

  1. [HEALTH] 2 sources
    Osaka Keisatsu Hospital reports successful first iPS cell heart sheet transplant

    A patient has successfully recovered following the world's first transplant of iPS cell-derived heart sheets, a breakthrough regenerative medicine treatment developed by QualiCEPT.

  2. [HEALTH] 11 sources
    Japan hospital performs first surgery using iPS heart muscle sheets

    Japanese surgeons have performed the first surgery using commercial iPS cell-derived heart muscle sheets to treat severe heart failure, marking a major milestone in regenerative medicine.

Sources

eldia.com · fnn.jp · ipc.digital · japantimes.co.jp · juruaemtempo.com.br · metropoles.com · myrepublica.nagariknetwork.com · newsmonkey.be · rpp.pe · udgtv.com · upday.com · viagemegastronomia.com.br · yomidr.yomiuri.co.jp