[REVISION HISTORY]

Melatonin use and heart failure risk study

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2026-09-26 15:37 UTC → 2026-10-23 22:46 UTC · added ~~removed~~

A preliminary observational study presented at the American Heart Association Scientific Sessions suggested a potential link between long-term melatonin use and an increased risk of heart failure. Analyzing ~~over 130,000 adults,~~ 130,828 adults with insomnia, researchers found that those using the supplement for at least 12 months had a approximately an 89% to 90% higher probability of developing heart failure within five years compared to non-users. Specifically, heart failure occurred in 4.6% of the melatonin-using group, compared to 2.7% in the control group. Lead researcher Ekenedilichukwu Nnadi noted that ‘melatonin supplements might not be as harmless as is commonly believed.’ Subsequent reporting emphasized that the study does not prove a cause-and-effect relationship. The observed association may result from ‘confounding by indication,’ meaning the underlying conditions requiring melatonin—such as anxiety, depression, or chronic insomnia—could be the actual drivers of cardiovascular risk. Additionally, the findings were presented as a conference abstract and had not yet undergone full peer review. Common side effects of melatonin, such as daytime drowsiness, headaches, dizziness, and nausea, were also noted. Recent scientific research has begun to reshape the debate regarding melatonin safety. While the initial study raised concerns, newer randomized controlled studies have not confirmed that melatonin causes heart damage. Furthermore, a recent meta-analysis suggests that the supplement may offer potential positive effects for certain patient groups.

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