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2 clusters · 3 sources · 3 days · First seen · Last updated

Oligodendrocyte dysfunction and cognitive decline research

Overview

Research has identified a link between dysfunctional oligodendrocytes—cells responsible for producing myelin—and age-related cognitive decline. Studies involving the Lothian Birth Cohort 1936 indicate that individuals experiencing more severe cognitive decline show changes in nerve fibers and the presence of excess, unhealthy myelin.

Further investigation published in Nature Medicine utilized mouse experiments to explore these mechanisms. Researchers found that deleting the gene encoding nuclear factor erythroid 2-related factor 2 (NRF2) from oligodendrocytes in mice resulted in axon size alterations and myelin thickness changes similar to those observed in humans. These findings suggest that reduced NRF2 expression and oligodendrocyte density are key factors in cognitive impairment.

Entities

Lothian Birth Cohort 1936 · Adelaide University · Nature Medicine · University of Edinburgh · UK Dementia Research Institute

Timeline

  1. 17 days ago

    [HEALTH] 2 sources
    Oligodendrocyte dysfunction linked to age-related cognitive decline

    A study in Nature Medicine suggests that dysfunctional oligodendrocytes, which produce the brain's myelin, may contribute to age-related cognitive decline in humans.

  2. 19 days ago

    [HEALTH] 2 sources
    Research links dysfunctional brain cells to age-related cognitive decline

    Research indicates that dysfunctional myelin-producing cells may drive cognitive decline in aging, while new studies at Adelaide University aim to investigate how neural noise affects memory and thinking.

Sources

adelaide.edu.au · news-medical.net · time.news