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[SITUATION] · [QUIET] · [HEALTH]

3 clusters · 6 sources · 24 days · First seen · Last updated

UCI Health pancreatic cancer laser therapy trial

Overview

UCI Health is conducting a first-in-human, phase 1 clinical trial using vascular targeted photodynamic therapy (VTP) to treat localized but inoperable pancreatic tumors. Developed by Israel-based ImPact Biotech, the treatment uses a light-sensitive drug called padeliporfin to destroy tumors encasing major abdominal arteries.

The goal of the therapy is to clear these vessels of tumor tissue to make patients eligible for life-saving surgical procedures. Of the six patients treated in the trial so far, four were able to undergo surgery to remove remaining tumor tissue, with three of those patients showing no evidence of cancer cells at the surgical margins.

This experimental technique involves administering padeliporfin and using a specific wavelength of light delivered via an optical fiber inside the artery. By damaging the small vessels feeding the tumor tissue near the artery, researchers aim to free the vessel for safe surgical intervention. This approach addresses a critical challenge in treating pancreatic ductal adenocarcinoma, where tumors wrapping around major abdominal arteries often make surgical removal too dangerous.

Entities

University of California, Irvine · ImPact Biotech · City of Hope · UCI Health · University of Adelaide

Timeline

  1. [HEALTH] 2 sources
    New light-based therapy targets inoperable pancreatic tumors

    A Phase 1 study is testing a light-based photodynamic therapy to make inoperable pancreatic tumors surgically removable by targeting vessels surrounding major arteries.

  2. [HEALTH] 2 sources
    Medical researchers test laser therapy and mRNA nanoparticles for cancer treatment

    New medical advancements include a Phase 1 trial using laser therapy to make pancreatic tumors operable and mRNA nanoparticles designed to reprogram immune cells to fight cancer.

  3. [HEALTH] 2 sources
    UCI Health conducts clinical trial using laser therapy for pancreatic cancer

    UCI Health is conducting a phase 1 clinical trial using laser-based photodynamic therapy to target inoperable pancreatic tumors, potentially making patients eligible for life-saving surgery.

Sources

doctorulzilei.ro · farmacoecura.it · news-medical.net · newswise.com · stiintasitehnica.com · stranotizie.it

This summary has been updated 1 time: see revision history