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2 clusters · 6 sources · 14 days · First seen · Last updated

Vitamin C clinical trial for blood disorders

Overview

The phase 2 EVITA clinical trial has investigated the effects of daily 1,000 mg oral vitamin C supplementation on 109 patients with precancerous blood disorders, specifically clonal cytopenia of undetermined significance (CCUS) and myelodysplastic syndrome (MDS).

Results from the randomized, double-blind, placebo-controlled study indicate that while the supplementation did not significantly change the growth rate of abnormal blood cell clones, it may offer survival benefits. Exploratory analysis showed that participants receiving vitamin C had significantly higher survival rates after approximately three years of follow-up compared to the placebo group.

Researchers also noted changes in cytokine levels associated with inflammation and immune signaling, as well as fewer adverse events in the treatment group. Because these findings are exploratory, researchers have emphasized the necessity for larger-scale phase 3 clinical trials to confirm these outcomes before making definitive medical recommendations.

Entities

Van Andel Institute · American Cancer Society · University of Copenhagen · Kirsten Grønbæk · Stand Up To Cancer

Timeline

  1. [HEALTH] 2 sources
    Vitamin C trial shows potential survival benefits in precancerous blood disorders

    A phase 2 clinical trial suggests that daily 1,000 mg oral Vitamin C supplementation may improve survival outcomes and reduce inflammation in patients with precancerous blood disorders like MDS.

  2. [HEALTH] 4 sources
    Vitamin C supplementation shows potential in phase 2 blood disorder trial

    A phase 2 clinical trial suggests 1,000 mg of daily oral vitamin C may improve survival rates in patients with certain precancerous blood disorders, though further phase 3 testing is required.

Sources

clinicalnews.org · consultantlive.com · insideprecisionmedicine.com · newswise.com · radio580.com.ni · scitechdaily.com