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Best Medicine season 2 premiere and broadcast schedule
Overview
The medical comedy-drama series ‘Best Medicine’ has returned for its second season on Fox. Following an early premiere on Sunday, September 20, which aired after football coverage, the series transitioned to its regular Tuesday night time slot.
The season premiere, ‘Be Careful What You Fish For’, introduced a time jump of several months and featured Dr. Martin Best managing a blood phobia while a mermaid reportedly washed ashore in Port Wenn. The episode also included guest star Andrea Martin as Judith and addressed the consequences of a sea urchin boom for characters Greg and George.
As the season progresses, the third episode, ‘Crate Expectations’, aired on October 6 and featured a floating crate race in Port Wenn. The fifth episode, ‘Hare Today, Gone Tomorrow’, aired on October 20, following a traveling magician duo whose visit turns tragic upon the death of the magician’s wife. This episode introduced Parker, played by Jack Cutmore-Scott, a new medical monitor for Martin that creates professional tension and a personal connection with Louisa Gavin. Additionally, Eden discovers a letter written by Martin to Louisa, causing personal complications.
The second season has been expanded to 14 episodes. New episodes air live on Fox on Tuesday nights, with subsequent streaming availability on Hulu and Disney+ on Wednesdays.
Production for the season took place in the Hudson Valley, utilizing extensive set designs including locations such as The Salty Breeze. The series continues to follow Dr. Martin Best, played by Josh Charles, as he navigates life in Maine. Returning cast members include Abigail Spencer, Josh Segarra, Annie Potts, and Cree, with Stephen Spinella and Jason Veasey promoted to series regulars.
Entities
Fox · Josh Charles · Abigail Spencer · Best Medicine · Hulu
Timeline
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[CULTURE] 3 sourcesBest Medicine airs season two, episode five on FOX
The FOX series ‘Best Medicine’ airs season two, episode five, ‘Hare Today, Gone Tomorrow,’ featuring a tragic medical case involving a magician’s wife and new character tensions.
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[CULTURE] 4 sourcesBest Medicine Season 2 continues on Fox
Fox’s medical dramedy ‘Best Medicine’ has returned for Season 2, with the third episode, ‘Crate Expectations,’ set to air on October 6, followed by streaming on Hulu and Disney+.
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[CULTURE] 5 sourcesFOX to premiere second season of Best Medicine
FOX will offer an early premiere of ‘Best Medicine’ Season 2 on Sunday, September 20, before its regular Tuesday schedule begins.
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[CULTURE] 2 sourcesFox series Best Medicine set to return for season two
Fox’s dramedy ‘Best Medicine’ returns for season two on September 22, 2026, featuring new plotlines involving a mermaid mystery and character developments for Dr. Martin Best.
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[CULTURE] 2 sourcesBest Medicine Season 2 trailer released by FOX
FOX has released the official Season 2 trailer for ‘Best Medicine’, which premieres on September 22 following a multi-month time jump in the series.
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[CULTURE] 3 sourcesBest Medicine set to return for Season 2 on Fox
Fox's medical comedy-drama 'Best Medicine' will return for a 14-episode second season starting September 22, 2026, following its recent success on Netflix.
Sources
bleedingcool.com · cinemablind.com · comicbasics.com · decider.com · emsworld.com · nypost.com · seat42f.com · seriouslyomg.com · showbizjunkies.com · tvline.com · tvseriesfinale.com
This summary has been updated 4 times: see revision history