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2 clusters · 5 sources · 8 days · First seen 24 days ago · Last updated 16 days ago

Biological mechanisms of skin aging and inflammation

Overview

Scientific research has identified specific molecular and biological drivers of age-related skin inflammation and aging. Initial findings led by Dr. Guiomar Solanas and Dr. Salvador Aznar Benitah highlight a mechanism where aging-related changes in skin stiffness alter the interaction between proteins BMAL1 and YAP. This shift causes the proteins to concentrate in DNA regions that control inflammatory genes, increasing their activity and disrupting epidermal homeostasis.

Subsequent studies have expanded this understanding by linking skin aging to genetic reprogramming and changes in the skin microbiome. Research from the Jackson Laboratory and Duke University suggests that the skin functions as an aging ecosystem where beneficial microorganisms decrease as potentially harmful ones proliferate. While current therapeutic focus remains on inflammatory diseases like atopic dermatitis, researchers indicate that modulating the skin microbiome may provide future pathways for promoting healthy aging.

Entities

IRB Barcelona · Nature Aging · Pediatric Cancer Center Barcelona · Guiomar Solanas · Salvador Aznar Benitah

Timeline

16 days ago

[HEALTH] 3 sources
Scientific studies reveal genetic and microbial drivers of skin aging
New research highlights that skin aging is driven by both genetic reprogramming that triggers inflammation and shifts in the skin microbiome ecosystem.
24 days ago

[HEALTH] 2 sources
Researchers identify molecular mechanism behind age-related skin inflammation
A study identifies how proteins BMAL1 and YAP drive age-related skin inflammation, while dermatological advice highlights the importance of soothing ingredients for maintaining a weakened skin barrier.

Sources

editions-dangles.com · lasemanapr.com · lavanguardia.com · libertaddigital.com · ma-clinique.fr